| Acronym | Definition |
|---|
| ISAM | Indexed Sequential Access Method |
| ISAM | Intelligent Services Access Manager |
| ISAM | International Society for Aerosols in Medicine |
| ISAM | Institute for Studies in American Music (Brooklyn College, City University of New York) |
| ISAM | International Symposium on Assembly and Manufacturing |
| ISAM | IBM (International Business Machine Corporation) Security Access Manager (software) |
| ISAM | Information Centre for Southern African Music |
| ISAM | Intelligent Systems and Advanced Manufacturing (symposium) |
| ISAM | Iraq Security Assistance Mission (US DoD) |
| ISAM | First Samuel |
| ISAM | Ionic Self-Assembled Monolayer |
| ISAM | Integrated Switching And Multiplexing |
| ISAM | Intermediate Software Acquisition Management Course (IRMC/DSMC, also known as SAM 201) |
| ISAM | Infant of a Substance Abusing Mother |