| Acronym | Definition |
|---|
| IRC | Internet Relay Chat |
| IRC | International Red Cross |
| IRC | International Residential Code |
| IRC | Information Resource Center |
| IRC | International Rescue Committee (New York, New York) |
| IRC | Institute for Research in Construction (Canada) |
| IRC | International Water and Sanitation Centre |
| IRC | Intercontinental Rally Challenge |
| IRC | International Relations Center |
| IRC | Indian River County (Florida) |
| IRC | International Reply Coupon (USPS) |
| IRC | Insuficiencia Renal Cronica (Spanish: Renal Failure) |
| IRC | Internal Revenue Code of 1986 (formerly 1954) |
| IRC | International Research Conference |
| IRC | Innovation Relay Centre |
| IRC | Independent Review Committee (various locations) |
| IRC | Interference Rejection Combining (telecommunications) |
| IRC | INEL (Idaho National Engineering Laboratory) Research Center |
| IRC | Innocenti Research Centre (UNICEF) |
| IRC | Interhemispheric Resource Center |
| IRC | Instructor Resource Center (various organizations) |
| IRC | Indie Rock Cafe |
| IRC | Islamic Research Center (various locations) |
| IRC | Innovation Relay Center |
| IRC | Incident Response Coordinator |
| IRC | Immigration Removal Centre (UK) |
| IRC | Internet Related Communication |
| IRC | Incident Response Committee |
| IRC | International Rally Challenge |
| IRC | Infra Red Camera |
| IRC | Interrupt Request Controller |
| IRC | Inter Region Communication |
| IRC | Infrared Remote Control |
| IRC | Insurance Research Council |
| IRC | Investment Review Committee (various organizations) |
| IRC | Interdisciplinary Research Centre |
| IRC | Imposto Sobre o Rendimento das Pessoas Colectivas (Portuguese tax) |
| IRC | International Rice Commission (Italy) |
| IRC | Internet Research Center (various locations) |
| IRC | International Rescue Corps (UK) |
| IRC | Institut de Recherche en Construction (French: Institute for Research in Construction; Canada) |
| IRC | Industrial Relations Committee (various organizations) |
| IRC | Irvine Ranch Conservancy (est. 2005; Irvine, CA) |
| IRC | Italian Resuscitation Council |
| IRC | Individual Restaurant Company (UK) |
| IRC | Inter-Residence Council |
| IRC | Inoue Rubber Company (Thailand) |
| IRC | Internal Review Committee |
| IRC | Inmate Reception Center (Orange County California Sheriff's Department) |
| IRC | Incident Response Capability |
| IRC | In-Row Cooling (data centers) |
| IRC | Industrial Relations Counselors (various organizations) |
| IRC | Indian Roads Congress |
| IRC | Intelligent Robotics and Communication Laboratories (Advanced Telecommunications Research Institute International; Japan) |
| IRC | Investor Relations Company (Chicago, IL) |
| IRC | Immigration Reform Caucus (US Congress) |
| IRC | Information and Referral Center |
| IRC | International Record Carrier |
| IRC | Industrial Resource Center (Erie, PA) |
| IRC | Islamic Religious Council |
| IRC | Illinois Reading Council |
| IRC | International Regulome Consortium |
| IRC | Industrial Research Chairs (Canada) |
| IRC | INFOSEC Research Council |
| IRC | Industrial Revitalization Corporation (Japan) |
| IRC | Integrated Remote Console |
| IRC | International Roadmap Committee |
| IRC | Italian Red Cross |
| IRC | Intake Release Center (Orange County Jail) |
| IRC | Information Research Corporation |
| IRC | Interim Report Committee (various organizations) |
| IRC | Incident Review Committee |
| IRC | Incrementally Related Carrier |
| IRC | Impôt sur le Revenu des Collectivités (French: Tax on Corporate Income; Luxembourg) |
| IRC | Instrument Remote Control (NASA/GSFC) |
| IRC | Indian Railways Corporation (Ministry of Railways) |
| IRC | Investor Relations Center (Philippines) |
| IRC | Infrared Reflective Coating |
| IRC | Icelandic Research Council |
| IRC | Instrument Refresher Course |
| IRC | Island Rallysport Club (Nanaimo, BC) |
| IRC | International Resort College (Japan) |
| IRC | Issue Resolution Conference (USACE) |
| IRC | Interreligious Council of Central New York (Syracuse) |
| IRC | Igor Righetti Comunicazione |
| IRC | Inspection Record Card |
| IRC | Indoor Recreation Centre |
| IRC | Investment Registration Certificate (Korea) |
| IRC | Infrastructure Renewals Charge (UK) |
| IRC | Interagency Radio Committee |
| IRC | Incremental Related Carrier (cable television) |
| IRC | International Reconciliation Coalition |
| IRC | Islamic Relief Committee |
| IRC | Immigration Reform Coalition |
| IRC | Instantly Redeemable Coupon |
| IRC | In-Room Connection |
| IRC | Inflatable Raiding Craft |
| IRC | Initial Ready Company (1st unit of DRF to deploy) |
| IRC | Inland Revenue Commissioner (various countries) |
| IRC | Information Resource Catalogue |
| IRC | Inland Revenue Code |
| IRC | International Resource Committee |
| IRC | Inspection Release Certificate |
| IRC | Inmate Records Coordinator |
| IRC | International Railways of Central America |
| IRC | Information and Research Center at King Hussein Foundation |
| IRC | Internet Restricting Country |
| IRC | Independent Recording Company (music store) |
| IRC | Item Responsibility Code |
| IRC | Investment Recovery Center |
| IRC | International Reference Center for Radioactivity |
| IRC | International Resistance Corporation |
| IRC | Integrated Radio Control |
| IRC | International Rome Convention |
| IRC | Infratools Remote Control (Peregrine Systems) |
| IRC | International Rewards Centre (est. 2002; New Zealand) |
| IRC | Initial Response Call |
| IRC | Initial Root Cause |
| IRC | Inventory Re-balancing Center |
| IRC | Inside Reactor Containment (nuclear plant) |