| Acronym | Definition |
|---|
| IRENE | International Restructuring Education Network Europe (labor organization) |
| IRENE | Institute for Research and Education on Negotiation in Europe (est. 1995) |
| IRENE | Institut de Recherche et d'Enseignement sur la Négociation en Europe (French: Institute for Research and Education on Negotiation in Europe) |
| IRENE | Image, Reconstruct, Erase Noise, Etc. (sound recording) |
| IRENE | Iniziative Ricerche Esperienze Nuova Europa (Italian: Experience New Europe Research Initiatives; Milan, Italy) |
| IRENE | Integrated Resources for Evaluating Numerical Estimates (software) |