| Acronym | Definition |
|---|
| JSC | Johnson Space Center (NASA) |
| JSC | Joint Stock Company |
| JSC | Journal of Symbolic Computation |
| JSC | Junior School Certificate (Bangladesh) |
| JSC | Joint Steering Committee |
| JSC | Johnson State College (Vermont) |
| JSC | Java Studio Creator |
| JSC | Java Swing Connection |
| JSC | Java Script Compiler |
| JSC | Jordan Securities Commission |
| JSC | Junior School Council (Australia) |
| JSC | Joint Scientific Committee |
| JSC | Joint Standing Committee |
| JSC | Joint Spectrum Center |
| JSC | Job Scheduling Console (software) |
| JSC | Joint Strategic Committee (US DoD) |
| JSC | Judicial Selection Commission (various locations) |
| JSC | Al Jazeera Satellite Channel (private news TV in Qatar) |
| JSC | Jewish Service Corps (various locations) |
| JSC | Short Circuit Current Density (semiconductor device property) |
| JSC | Junior Supporters Club (various locations) |
| JSC | Japan Shiatsu College (Tokyo, Japan) |
| JSC | Jade Software Corporation (various locations) |
| JSC | Japanese Society of Canterbury (est. 1992; New Zealand) |
| JSC | Jericho Sailing Centre (Canada) |
| JSC | Joint Sectoral Committee |
| JSC | Johnstone Shire Council (Australia) |
| JSC | Joint Subcommittee |
| JSC | Judicial Standards Commission |
| JSC | Justice and Safety Center |
| JSC | Japanese Society of Cinematographers |
| JSC | Joint Supercomputer Center |
| JSC | Judiciary/Supreme Court |
| JSC | Japan Ship Centre (JETRO) |
| JSC | Junior Staff Course (various armed forces) |
| JSC | Jacob Sheep Conservancy |
| JSC | Joint Security Control (WWII US organization, subordinate to the JCS; responsible for security/codebreaking/deception operations) |
| JSC | Joshua Scott Chasez (NSYNC) |
| JSC | Junior Sailing Committee |
| JSC | Judge of Superior Court (New Jersey) |
| JSC | Junction Space Charge region (semiconductors) |
| JSC | Joint Strategic Capability |
| JSC | Jóvenes sin Censura (Spanish: Young People Without Censorship) |
| JSC | Jason Standard Corp. |
| JSC | Johnstown and Stony Creek Railroad (sometimes seen as JHSC) |
| JSC | JPL (Jet Propulsion Laboratory) Space Calendar (US NASA) |