| Acronym | Definition |
|---|
| LSB | Lock, Stock & Barrel |
| LSB | LINUX Standard Base |
| LSB | Lutheran Service Book |
| LSB | Laboratory Services Branch (various locations) |
| LSB | Lisbon |
| LSB | Linux Standards Base |
| LSB | Least Significant Byte |
| LSB | Lumbar Sympathetic Block |
| LSB | Liberty Savings Bank (various locations) |
| LSB | Lower Sideband (radio transmission mode) |
| LSB | Legal Services Board |
| LSB | Leavey School of Business (Santa Clara University) |
| LSB | Laguna Seca Blue (BMW auto color) |
| LSB | Life Sciences Branch (Statistics Canada) |
| LSB | Laconia Savings Bank (New Hampshire) |
| LSB | Large Square Bale (hay) |
| LSB | Low Surface Brightness (galaxies) |
| LSB | Legal Studies in Business (various schools) |
| LSB | Lokaal Sociaal Beleidsplan (Dutch: Local Social Policy; Belgium) |
| LSB | Lower Side Band |
| LSB | Lincoln State Bank (various locations) |
| LSB | Long Sleeve Blue (US Air Force) |
| LSB | Landing Support Battalion (USMC) |
| LSB | Least Significant Bit/Byte |
| LSB | Long Spine Board |
| LSB | Local Standards Board (various organizations) |
| LSB | Less Said the Better (idiom) |
| LSB | Lone Star Bank |
| LSB | Lower Sternal Border |
| LSB | Landing Ship Barge |
| LSB | Landing Ship, Bombardment (hull classification; US Navy) |
| LSB | Locus-Specific Bracket |
| LSB | Last Stage Blade |
| LSB | Labor Standards Bureau |
| LSB | Launch Support Building |
| LSB | Liceo Secretarial Bilingue (Guatemalan private school) |
| LSB | Level Status Block |
| LSB | Light Splitter Bank |
| LSB | Lakeshore Symphonic Band (Cedarburg, WI) |
| LSB | Logistics Support Base |
| LSB | List of Successful Bidders |
| LSB | Logic and Systems Biology (Workshop) |