| Acronym | Definition |
|---|
| LSE | London School of Economics & Political Science (London, England, UK) |
| LSE | Lease (classifieds) |
| LSE | London Stock Exchange |
| LSE | Loose |
| LSE | London South East (financial website; UK) |
| LSE | Low Self-Esteem |
| LSE | Lahore School of Economics (Pakistan) |
| LSE | Life-Skills Education |
| LSE | Life Skills Education (UNICEF) |
| LSE | Low Surface Energy (physics) |
| LSE | Least Squares Estimate |
| LSE | Load-Serving Entity |
| LSE | Lahore Stock Exchange (Pakistan) |
| LSE | Local Search Engine |
| LSE | Limited Signature Edition |
| LSE | Liga Studentilor Electronisti (Romanian student league) |
| LSE | Large Scale Event (various organizations) |
| LSE | Large Scale Enterprise |
| LSE | Life Support Equipment |
| LSE | London School of English (London, England, UK) |
| LSE | Language Sensitive Editor |
| LSE | Living Skin Equivalent |
| LSE | Lead System Engineer |
| LSE | Landing Signal Enlisted |
| LSE | Life Style Extra (UK) |
| LSE | Logistics Support Element |
| LSE | La Crosse, WI, USA - La Crosse Municipal (Airport Code) |
| LSE | Leadership Self-Efficacy (management) |
| LSE | Logistics Support Equipment |
| LSE | Large-Sized Enterprise (Brussels, Belgium) |
| LSE | Launch Support Equipment |
| LSE | Local Software Economy |
| LSE | Lincoln Southeast High School (Lincoln, Nebraska) |
| LSE | Licensed Structural Engineer |
| LSE | Local Subscriber Environment |
| LSE | Laboratory Support Equipment |
| LSE | Live Sheep Export |
| LSE | Linux Software Encyclopedia |
| LSE | Longitudinal Section Electric (mode) |
| LSE | Limite Supérieure d'Explosibilité (French: Upper Flammable Limit) |
| LSE | Left Sternal Edge (auscultation of heart sounds) |
| LSE | Land Surface Experiment |
| LSE | Least Side-Lobe Energy |
| LSE | Log-Spectral-Error |
| LSE | Local Surety Exercise |