| Acronym | Definition |
|---|
| LSU | Louisiana State University |
| LSU | La Sierra University |
| LSU | Lavoratori Socialmente Utili (Italian: Socially Useful Workers) |
| LSU | Load Store Unit (computing) |
| LSU | Large Subunit |
| LSU | La Salle University (Philadelphia, PA) |
| LSU | Load Source Unit |
| LSU | Line Server Unit |
| LSU | Leningrad State University (Russia) |
| LSU | Learning Support Unit |
| LSU | Link State Update (OSPF) |
| LSU | Liverpool Students' Union (UK) |
| LSU | Leyte State University (formerly Visayas State College of Agriculture) |
| LSU | Laerdal Suction Unit |
| LSU | Lambda Sigma Upsilon (Latino fraternity) |
| LSU | Language Support Unit (various locations) |
| LSU | La Sainte Union (London) |
| LSU | Laser Scanning Unit |
| LSU | Landing Ship Utility |
| LSU | Loughborough Students' Union (UK) |
| LSU | Life Support Umbilical (US NASA) |
| LSU | Loran Support Unit (USCG) |
| LSU | Life Support Unit |
| LSU | LAN Service Unit |
| LSU | Loan Status Update |
| LSU | Labor Service Unit |
| LSU | Laboratoire de Spectroscopie Ultrarapide (French: Ultrafast Spectroscopy Laboratory; Switzerland) |
| LSU | Line State Unknown (Cisco) |
| LSU | Life Savers Underground |
| LSU | Local Synchronization Utility |
| LSU | Launcher Selector Unit |