| Acronym | Definition |
|---|
| LESA | Land Evaluation and Site Assessment |
| LESA | Law Enforcement Support Agency (911 dispatch center) |
| LESA | Least Sandpiper (bird species Calidris minutilla) |
| LESA | Landlord's Energy Saving Allowance (UK) |
| LESA | Livingston Educational Service Agency |
| LESA | Lifestyle Enrichment for Senior Adults (Canada) |
| LESA | limited English-speaking ability |
| LESA | Laboratoire des Études Sémitiques Anciennes (French) |
| LESA | Logistics Execution Systems Association |
| LESA | Logistics Element Support Activity |
| LESA | Large Aircraft Enhanced Situational Awareness (US DoD) |
| LESA | Lewis Engineers and Scientists Association |
| LESA | Local Environment System Architecture |
| LESA | liposomally entrapped second antibody |
| LESA | low effective specific activity |
| LESA | Life Event Scale for Adolescents |