| Acronym | Definition |
|---|
| LESC | London E-Science Centre |
| LESC | Law Enforcement Support Center (US Immigration and Customs Enforcement) |
| LESC | Lower Eastside Service Center |
| LESC | Loch Earn Sailing Club (UK) |
| LESC | Lake Elsinore Soaring Club (aviation) |
| LESC | Lockheed Engineering and Sciences Company |
| LESC | Lake Eustis Sailing Club (Florida) |
| LESC | Limbal Epithelial Stem Cell |
| LESC | Life, Earth and Environmental Standing Committee (European Science Foundation) |
| LESC | Lifecycle Engineering Solutions Center |
| LESC | London Electric Supply Corporation, Ltd. |
| LESC | Lockheed Electronic Systems Company |
| LESC | Logistics Executive Steering Committee |
| LESC | Light Engineering Service Center (Pakistan) |