| Acronym | Definition |
|---|
| OPAL | Orchestration and Provisioning Automation Library |
| OPAL | Optical Automatic Library |
| OPAL | Online Presentation Access Library |
| OPAL | Optimized Portable Application Libraries |
| OPAL | Open Process Adapter Library |
| OPAL | Oregon Parallel Logic |
| OPAL | Open Process Automation Library |
| OPAL | Open Air Laboratories Network (nature initiative; UK) |
| OPAL | Open Phone Abstraction Library |
| OPAL | Open Process Automation Library (IBM) |
| OPAL | Open Physics Abstraction Layer |
| OPAL | Outstanding Projects and Leaders (ASCE Award) |
| OPAL | Open Pool Australian Light-Water (reactor) |
| OPAL | Online Public Access in Libraries |
| OPAL | Online Permit Assistance and Licensing (New York) |
| OPAL | Ontario Protocol Assessment Level (oncology; Canada) |
| OPAL | Omni-Purpose Apparatus for LEP (experiment at the CERN physics laboratory) |
| OPAL | Office of Pluralism and Leadership (Dartmouth College; Hanover, NH) |
| OPAL | Orchestration and Provisioning Automation Library (IBM) |
| OPAL | ONGC (Oil and Natural Gas Corporation) Petro Additions Limited (India) |
| OPAL | Oracle, PHP, Apache and Linux |
| OPAL | Organized Parents Against Lead |
| OPAL | Officer Promotion Authorization Listing |
| OPAL | Optical Program Algorithm |
| OPAL | Oberlin Peace Activists League (Oberlin College; Ohio) |
| OPAL | Operation Progress and Alert |
| OPAL | Outfitting Publication Applicability List |
| OPAL | Optical Access Lines (Deutsche Telekom) |
| OPAL | Optimal Aging & Longevity (Houston, TX clinic) |
| OPAL | Optical Armament Link |
| OPAL | Optical Platform Alignment Linkage |
| OPAL | Optimized Applicative Language (computer programming) |
| OPAL | Option Action List |
| OPAL | Object Process Alignment |