| Acronym | Definition |
|---|
| KSC | Kennedy Space Center |
| KSC | Keene State College (New Hampshire) |
| KSC | Knights of St. Columba (UK) |
| KSC | King Street Center (Burlington, VT) |
| KSC | Kagoshima Space Center |
| KSC | Karlsruher Sportclub (Karlsruhe, Germany) |
| KSC | Key Selection Criteria (employment qualifications) |
| KSC | Korean Service Corps |
| KSC | Kista Science City (Electrum Foundation; Anaheim, CA) |
| KSC | Keyboard and System Controller (Intel) |
| KSC | Komunisticka Strana Ceskoslovenska (Communist Party of Czechoslovakia) |
| KSC | Keck Science Center (Claremont, CA) |
| KSC | Kelsey-Seybold Clinic (Houston, TX; est. 1949) |
| KSC | Kyocera Solar Corporation (Japan) |
| KSC | Kosice, Slovakia - Barca (Airport Code) |
| KSC | Kansas State College |
| KSC | Kennedy Spaceflight Center |
| KSC | Kissimmee Surgery Center (Florida) |
| KSC | Kirkwood Soccer Club (New Castle, Delasare) |
| KSC | Kofu Shima Corporation (manufacturer; Japan) |
| KSC | Kuwait Shareholding Company |
| KSC | Keepers of The Sacred Chao (Golden Apple Corps) |
| KSC | Keeper of the Sacred Chao (member of Discordian Society) |
| KSC | Kingland Systems Corporation |
| KSC | KillerSquirrels.com |
| KSC | Kuwait Styrene Company |
| KSC | Korean Solidarity Committee |
| KSC | Knutsford Safety Consultancy (UK) |
| KSC | Kinship Support Center |
| KSC | King Solomon College (Gold Coast, Australia) |
| KSC | Kentuckiana Scooter Club |
| KSC | Kwajalein Scuba Club |