| Acronym | Definition |
|---|
| LOE | Low Earth Orbit |
| LOE | League of Explorers (Hearthstone: Heroes of Warcraft Expansion) |
| LOE | Ley Orgánica de Educación (Spanish) |
| LOE | Legend of Edda (role-playing game) |
| LOE | Legends of Equestria (gaming) |
| LOE | Level Of Effort |
| LOE | Lack of Efficacy |
| LOE | Level of Evidence (evidence-based medicine) |
| LOE | Lights Out Edition |
| LOE | Law on Enterprises (Vietnam) |
| LOE | Language Other than English. |
| LOE | Limited Objective Experiment |
| LOE | Letter of Explanation |
| LOE | Lack of Effort |
| LOE | Live Operating Environment |
| LOE | Loss Of Energy |
| LOE | Loss of Exclusivity (pharmaceuticals going off-patent) |
| LOE | Letter Of Evaluation |
| LOE | Letter of Equivalency |
| LOE | Letter of Engagement |
| LOE | Line Operational Evaluation (aviation; Advanced Qualification Program) |
| LOE | Line of Effort (US DoD; US NASA) |
| LOE | Length of Employment |
| LOE | Line Oriented Evaluation |
| LOE | Lesbians On Ecstacy (band) |
| LOE | Letter Of Employment |
| LOE | Light-Off Examination |
| LOE | Lack of Entertainment |
| LOE | Limit of Error |
| LOE | Legacy of Excellence (award) |
| LOE | Lost on Earth (gaming) |
| LOE | Learning and Organizational Effectiveness |
| LOE | Love, As Ever (complimentary closing to letters of endearment) |
| LOE | Landing on Earth |
| LOE | Limit Of Exploitation |
| LOE | Loss Of Effect |
| LOE | Life of Edition (publishing) |
| LOE | Loss of Excitation (generator protection) |
| LOE | Legends of Eternity |
| LOE | Letter of Excellence |
| LOE | Level of Edit |
| LOE | Line of Engagement |
| LOE | Legions of Evil (computer game) |
| LOE | Loss of Earning Evaluation |
| LOE | Lease and Operating Expense |
| LOE | Local Order Entry |
| LOE | Lords of Eriador (gaming guild) |
| LOE | Length of Engagement |
| LOE | Limited Object Expert (related to Business Objects in IT software development) |
| LOE | Lesão Ocupando do Espaço (Portuguese: Occupying Lesion Area; neurology) |
| LOE | Living Off Equity |
| LOE | Letter of Execution |
| LOE | Left Otitis Externa |
| LOE | Loyal Order of Elbows |
| LOE | Loyalty Over Everything (band) |
| LOE | Liquid Organic Energy (vegetable oil and fat fuel) |
| LOE | Level-Over-Ethernet |
| LOE | Limit of Operating Envelope (nuclear power operation) |