| Acronym | Definition |
|---|
| MESI | Modified Exclusive Shared and Invalid |
| MESI | Modified Exclusive Shared Invalid (states of cache memory) |
| MESI | Monitoring, Evaluation and Surveillance Interface (Haïti) |
| MESI | Monthly Economic and Social Indicators (Australia) |
| MESI | Medical Event of Special Interest (clinical trials) |
| MESI | Mangled Extremity Syndrome Index |
| MESI | Multi Edit Software, Inc. (text editing software) |
| MESI | Marine and Environmental Studies Institute (College of the Bahamas) |
| MESI | Marocchinerie e Scamoscerie Italiane (Italian: Italian Saddlery and Tannery; est. 1907; Turin, Italy; sheepskin leather) |