| Acronym | Definition |
|---|
| MDI | Modern(ized) Demolition Initiators |
| MDI | Multiple Document Interface |
| MDI | Mount Desert Island (Maine, USA) |
| MDI | Metered-Dose Inhaler (International Pharmaceutical Aerosol Consortium) |
| MDI | Management Development Institute (India) |
| MDI | Mentor, Discover, Inspire (men's group) |
| MDI | Michelson Doppler Imager |
| MDI | Mazda Digital Innovation |
| MDI | Meta Data Interchange |
| MDI | Map Definition |
| MDI | Multi Drawing Interface |
| MDI | Machine Debugger Interface |
| MDI | Media Dependant Interface |
| MDI | Meldpunt Discriminatie Internet (Dutch: Internet Discrimination Hotline) |
| MDI | Medium Dependent Interface (IEEE) |
| MDI | Multiple Daily Injections (insulin) |
| MDI | Manual Data Input |
| MDI | Media Delivery Index (video monitoring) |
| MDI | Motor Development International (Luxemburg and France) |
| MDI | Microsoft Document Imaging |
| MDI | Media Dependent Interface |
| MDI | Medical Devices International (Alpharetta, GA) |
| MDI | Mini Dental Implant |
| MDI | Mental Developmental Index |
| MDI | Maximum Demand Indicator (electricity) |
| MDI | Ministerium des Innern (Department of the Interior, former East Germany) |
| MDI | Monolithic Dome Institute (Italy, TX) |
| MDI | Markaz-Ud-Dawa-Wal-Irshad (Muslim organization, India) |
| MDI | Multidirectional Instability |
| MDI | Model-Driven Integration (software design) |
| MDI | Missouri Department of Insurance |
| MDI | Mobile Data Initiative |
| MDI | Metal Detectors, Inc. (Oregon) |
| MDI | Miss Distance Indicator |
| MDI | Methylene Diphenylene Diisocyanate |
| MDI | Michigan Dyslexia Institute, Inc (Lansing, Michigan) |
| MDI | Media Dynamics, Inc. (Nutley, NJ) |
| MDI | Monitoring Division Incorporated |
| MDI | Memory Display Interface |
| MDI | Montgomery Design International (Westmont, IL) |
| MDI | Mission Dependency Index |
| MDI | Mean Daily Intake |
| MDI | Multiplex Device Interface |
| MDI | Multiple Dose Inhaler |
| MDI | Medically-Determined Impairment |
| MDI | Minor Disciplinary Infractions (various US military branches) |
| MDI | Managing for Daily Improvement |
| MDI | Multiple Dwelling Inspector (New Jersey) |
| MDI | Madawaska Doors, Inc. (Canada) |
| MDI | Market Development Index |
| MDI | Minimum Discriminative Information |
| MDI | Mutual Design and Implementation |
| MDI | Mechanical Design Integration |
| MDI | Management of Digital Information (Drexel University; Philadelphia, PA) |
| MDI | Manual Data Interchange |
| MDI | Metric-Driven Incentives |
| MDI | Managed Desktop Infrastructure |
| MDI | Message Data Interface |
| MDI | Masters in Disruptive Innovation (Hult International Business School; various locations) |
| MDI | Mixer Diode Implant |
| MDI | Modified Dipole Interaction |
| MDI | Military Disabling Injury |
| MDI | Meets Design Intent (Ford Motor Company) |
| MDI | Multimedia Document Interface |
| MDI | Microsoft Data Interchange |
| MDI | Multi-purpose Digital Indicator |
| MDI | Modern Demolition Initiation |
| MDI | Minimum Detectable Irradiance |
| MDI | Mobil Data International, Incorporated |
| MDI | Multiprofessional Directorate Intranet (Healthcare) |
| MDI | Munazzamat el da Wa Al'islamiya |
| MDI | Millennium Development Indicator |
| MDI | Metropolitan Door Industries Corp. (Garden City Park, NY) |
| MDI | Mines Development Inc. |
| MDI | Marketing Dimensions, Inc. (est. 1999) |