| Acronym | Definition |
|---|
| MLB | Major League Baseball |
| MLB | Minor League Baseball |
| MLB | Miraculous Ladybug (anime) |
| MLB | Middle Linebacker (football) |
| MLB | Money Line Betting (gambling) |
| MLB | Mortgage Loan Broker |
| MLB | Matt Leblanc (actor) |
| MLB | Mouseless Browsing (Mozilla Firefox) |
| MLB | Mille Lacs Band (Ojibew tribe; Minnesota) |
| MLB | Multiple Library |
| MLB | Missing Left Bracket |
| MLB | Media Library |
| MLB | Macro Library |
| MLB | Mother Love Bone (band) |
| MLB | Majesty Lord Blaster |
| MLB | Merrill Lynch Bank |
| MLB | Morgan Lewis & Bockius (international law firm) |
| MLB | Motor Life Boat |
| MLB | Main Logic Board |
| MLB | Multi-Layer Board |
| MLB | Medium to Large Business |
| MLB | Maritime Lumber Bureau |
| MLB | Mystery Lovers Bookshop (various locations) |
| MLB | Melbourne, FL, USA - Melbourne Regional Airport (Airport Code) |
| MLB | MacKimmie Library Block (University of Calgary; Canada) |
| MLB | Multi-Line Business |
| MLB | Mark Lanegan Band |
| MLB | Mainland Bridge |
| MLB | Metallic Link Belt |
| MLB | March of the Light Brigade |
| MLB | Intermediate Life Boat |
| MLB | Multinational Logistics Base |
| MLB | Michael Brittin Enterprises (NASA) |
| MLB | Mobile Logistics Support Base |
| MLB | Movable Lane Barrier |
| MLB | microlaryngotracheobronchoscopy |
| MLB | Material Labor Burden |
| MLB | Median Longitudinal Bundle |
| MLB | Medium Lead Burst Neuron (neurophysiology) |