| Acronym | Definition |
|---|
| MDK | Mandrake (Linux distribution) |
| MDK | Miejski Dom Kultury (Polish: Municipal House of Culture) |
| MDK | Medizinischer Dienst der Krankenkassen (German: Medical Service of Health Insurance) |
| MDK | Mix Development Kit |
| MDK | Microcontroller Development Kit (various companies) |
| MDK | Murder Death Kill (game) |
| MDK | Modem Development Kit |
| MDK | Mandrake |
| MDK | Moo Duk Kwan (Korea martial arts school) |
| MDK | Mujhse Dosti Karoge (Hindi movie) |
| MDK | Multimedia Development Kit |
| MDK | Most Dope Kids (gaming clan) |
| MDK | Mac da Knife Recordings |
| MDK | Max Doctor Kurt (protagonists of the game MDK) |
| MDK | Mass Destruction Krew (game) |
| MDK | Mine Detection Kitty |
| MDK | MD and Knowledge (UK band) |
| MDK | Mekanïk Destrukïw Kommandöh (Magma album) |
| MDK | Modern Developers Kit |