| Acronym | Definition |
|---|
| MDO | Madison (Amtrak station code; Madiscon, FL) |
| MDO | Multidisciplinary Design Optimization |
| MDO | Message Definition Object |
| MDO | Media Organization |
| MDO | Microsoft Development Object |
| MDO | Medium Density Overlay (engineered plywood) |
| MDO | Multi-Domain Operations (US Army) |
| MDO | Multidisciplinary Optimization |
| MDO | Marine Diesel Oil |
| MDO | Medical Defence Organisation (various locations) |
| MDO | Mission Driven Organization |
| MDO | Malaysia Debate Open |
| MDO | Membership Development Officer (various organizations) |
| MDO | Mentally Disordered Offender |
| MDO | Multiple Drug Overdose |
| MDO | Medical Doctor's Office |
| MDO | Machine Direction Orientation (polyetheylene sheeting) |
| MDO | Mothers Day Out |
| MDO | Minimum Distribution Option (finance) |
| MDO | Microenterprise Development Organization |
| MDO | Mass Distribution Operation |
| MDO | Monthly Debit Ordinary (insurance) |
| MDO | Military Deception Officer (US Air Force) |
| MDO | Market Delivery Operation (Sears) |
| MDO | Market Development Organisation |
| MDO | Methodist Diaconal Order |
| MDO | Maori Day Off |
| MDO | Mccauley Daye O'Connell Architects (Dublin, Ireland) |
| MDO | Manager Distribution Operations |
| MDO | Motor Diesel Oil |
| MDO | Medical Defense Officer |
| MDO | Marine-Safety Duty Officer |
| MDO | Most Desired Outcome (negotiation goal) |
| MDO | Multi-State Dependent Operation |