| Acronym | Definition |
|---|
| MCIS | Microsoft Commercial Internet System |
| MCIS | Microsoft Commercial Internet Service |
| MCIS | Microsoft Content Indexing Services |
| MCIS | Motion Control Information System |
| MCIS | Marikina Christian Integrated School (Marikina, Philippines) |
| MCIS | Master of Computer and Information Science (Cleveland State University; Cleveland, OH) |
| MCIS | Mellon Collie and the Infinite Sadness (Smashing Pumpkins album) |
| MCIS | Management Consultancy Information Service |
| MCIS | Malaysian Cooperative Insurance Society (currently MCIS Insurance Berhad) |
| MCIS | Map and Chart Information System |
| MCIS | MSRT Cosite Interference Suppressor |
| MCIS | Maintenance Control Information System |
| MCIS | Materiel Change Information System |
| MCIS | MHS (Military Health System) Cyberinfrastructure Services (US DoD) |