| Acronym | Definition |
|---|
| OPE | Office of Personnel |
| OPE | Outdoor Power Equipment |
| OPE | Office of Planning and Evaluation |
| OPE | Office of Postsecondary Education (Department of Education) |
| OPE | Online Professional Education |
| OPE | Oficina de Proyectos Especiales (Spanish: Office of Special Projects; Peru) |
| OPE | Open Publishing Environment |
| OPE | Offre Publique d'Echange |
| OPE | Office of Postdoctoral Education (various locations) |
| OPE | Overfill Protection Equipment (fueling equipment) |
| OPE | Operator Product Expansion |
| OPE | Oshkosh Placement Exchange (University of Wisconsin, Oshkosh) |
| OPE | Operational Planning Element |
| OPE | Overseas Processing Entity |
| OPE | One Pion Exchange |
| OPE | Other People's Experience |
| OPE | Out of Pocket Expense |
| OPE | Other Payroll Expenses (accounting) |
| OPE | Open Pulmonary Embolectomy |
| OPE | Our Precious Essence |
| OPE | Optical Proximity Effect |
| OPE | Other Plant Equipment |
| OPE | Overall Production Efficiency |
| OPE | Operational Preparation of the Environment |
| OPE | Orange Park Elementary (Orange Park, FL) |
| OPE | Open-Point Expanding |
| OPE | Outside Plant Engineer (various companies) |
| OPE | Office of Procurement Executive |
| OPE | Oregon, Pacific, and Eastern Railway Company |
| OPE | ORU Protective Enclosure |
| OPE | One Person Enterprise (business designation) |
| OPE | Office of Physical Education |
| OPE | Outdoor Product Exchange |
| OPE | Office of Performance and Evaluation (Idaho) |