| Acronym | Definition |
|---|
| NISC | NGO (Non-Governmental Organisation) Information and Support Centre |
| NISC | National Information Solutions Cooperative |
| NISC | National Invasive Species Council (US Department of the Interior) |
| NISC | National Inquiry Services Centre (South Africa) |
| NISC | Network Information and Support Center |
| NISC | National Information Services Corporation |
| NISC | National Institute of Senior Centers |
| NISC | National Interest Security Company (Fairfax, VA) |
| NISC | Nationwide Investment Services Corporation (Nationwide Financial) |
| NISC | National Indoor Sports Centre (Jamaica) |
| NISC | Netherlands International Shooting Competition (military competition) |
| NISC | Northern Ireland Supporters Club (UK) |
| NISC | Network Information Systems Center (Internet) |
| NISC | National Institute of Statistics and Census (various locations) |
| NISC | Naval Intelligence Support Center |
| NISC | No-Instruction-Set-Computer (design synthesis tools) |
| NISC | NAS Implementation Support Contract |
| NISC | NSA ISSO Service Center |
| NISC | National Integrated Service Center (Sprint) |
| NISC | Names in South Carolina (resource) |
| NISC | Network Infrastructure Support System |
| NISC | Nexus Information Sources Company Pte Ltd. (Singapore) |
| NISC | National / International Switching Center |