| Acronym | Definition |
|---|
| MPSM | Multi Protocol Service Module |
| MPSM | Multiprotocol Service Module (Cisco) |
| MPSM | Multi Player Soccer Manager (video game) |
| MPSM | Multi-Purpose Sub-Munition (ordnance type) |
| MPSM | Majlis Pembangunan Sumber Manusia (Malay: Human Resources Development Council; Malaysia) |
| MPSM | Michigan Program in Survey Methodology (est. 2001; University of Michigan; Ann Arbor, MI) |
| MPSM | Mucopolysaccharidosis-Mild Form (lysosomal storage disease) |
| MPSM | Microscopic Pedestrian Simulation Model (computer simulation) |
| MPSM | Mining Projects Safety Management (Australia) |