| Acronym | Definition |
|---|
| OFC | Office |
| OFC | Of Course |
| OFC | Officer |
| OFC | Olayan Financing Company |
| OFC | Oxygen Free Copper |
| OFC | Old Fashioned Christmas |
| OFC | Original Female Character (fanfiction) |
| OFC | Oceania Football Confederation (soccer) |
| OFC | Optical Fiber Cable |
| OFC | Oilfield Chemicals |
| OFC | Optical Fiber Communications |
| OFC | Order Fulfillment Center |
| OFC | Office Code (Sprint) |
| OFC | Orofacial Cleft |
| OFC | Orbital Frontal Cortex |
| OFC | Offshore Financial Center |
| OFC | Opportunity for Change (school system program to help troubled children) |
| OFC | Oxford Farming Conference (UK) |
| OFC | Optical Fiber Coupler |
| OFC | Official Fan Club |
| OFC | Ohio Fried Chicken (Jake Paul song) |
| OFC | Options for Change (Newburyport, MA) |
| OFC | Olanzapine/Fluoxetine Combination |
| OFC | Optical Fiber Conference (IEEE communications society) |
| OFC | Optional Federal Charter (US insurance regulations) |
| OFC | Optical Fiber Communication |
| OFC | Open Fiber Control |
| OFC | Output Flow Control |
| OFC | Open Financial Connectivity |
| OFC | Optical Fiber Conference |
| OFC | Open Future Concept |
| OFC | Ozark Folk Center (Mountain View, AR) |
| OFC | Oregon Fire Code |
| OFC | Other Female Character |
| OFC | Otemachi Financial City (office complex; Tokyo, Japan) |
| OFC | Open Financial Connectivity (Intuit, Microsoft And Checkfree) |
| OFC | Outside Front Cover |
| OFC | Open Food Challenge |
| OFC | Oklahoma Food Cooperative (Oklahoma City, OK) |
| OFC | Objective Force Capabilities |
| OFC | Organization For Combat |
| OFC | Oral Fluid Challenge |
| OFC | Old First Church |
| OFC | Operation First Casualty (political protest) |
| OFC | Odivelas Futebol Clube (Portuguese football club) |
| OFC | Oxide Fuels Complex |
| OFC | Occipitofrontal Circumference |
| OFC | Ontario Fitness Council (Canada) |
| OFC | Optical Fiber, Conductive (ITS) |
| OFC | Oxyfuel Gas Cutting (cutting/welding) |
| OFC | Office of Handicapped Concerns (Oklahoma) |
| OFC | Omega Force Clan (gaming clan) |
| OFC | Open Fibre Control (Paroli) |
| OFC | Offenbacher Fussball Club |
| OFC | Omron Finance Canada |
| OFC | Open Friction Course (asphalt roadway paving material) |
| OFC | Open File Connection |
| OFC | Other Foreign Currency |
| OFC | Order Fulfillment Council |
| OFC | Overflowing Cylinder |
| OFC | Operations and Facilities Council |
| OFC | Old Fart Clan (gaming, Day of Defeat Clan) |
| OFC | Oil & Filter Change |
| OFC | Overhead Foxhole Cover |
| OFC | Optional Forward Call Indicator (CCS #7/ITU-T) |
| OFC | Optical Filter Card |
| OFC | Ormond Football Club |
| OFC | Old Fine Canadian (whisky) |