| Acronym | Definition |
|---|
| NSSC | National School Safety Center |
| NSSC | Nippon Steel & Sumikin Stainless Steel Corporation (Japan) |
| NSSC | National Soil Survey Center |
| NSSC | National Senior Service Corps |
| NSSC | Naval Sea Systems Command |
| NSSC | National Strategy to Secure Cyberspace |
| NSSC | Nippon Steel & Sumikin Chemical (chemical manufacturing company; various locations) |
| NSSC | NASA Standard Spacecraft Computer |
| NSSC | National Supply Service Center (Indian Health Service) |
| NSSC | National Space Science Centre (UK) |
| NSSC | Nicholas School Student Council (Duke University; North Carolina) |
| NSSC | Naval Submarine Support Center |
| NSSC | Nul System Services Corporation (Nihon Unisys, Ltd.) |
| NSSC | Naval Submarine Support Command |
| NSSC | Neutral Sulfite Semi-Chemical |
| NSSC | National Space Studies Center (Air University; Montgomery, AL) |
| NSSC | Nuclear Security Services Corporation (Willowbrook, IL) |
| NSSC | Nittetsu Steel Sheet Corporation (Japan) |
| NSSC | National Syrian Seismological Center |
| NSSC | NORAD Space Surveillance Center |
| NSSC | National Secondary Student Council |
| NSSC | North Suburban Service Council (New Jersey) |
| NSSC | Naval Sea Support Center |
| NSSC | Normal Size, Shape, and Consistency |
| NSSC | National Syndromic Surveillance Conference (diseases) |
| NSSC | NAVAIR Systems and Software Support Center (Patuxent River, Maryland) |
| NSSC | Never Self-Synchronizing Code |