| Acronym | Definition |
|---|
| MSFC | Marshall Space Flight Center |
| MSFC | Multilayer Switch Feature Card (Cisco Systems) |
| MSFC | Multilayer Switch Feature Card |
| MSFC | Medical Students For Choice |
| MSFC | Metropolitan Sports Facilities Commission (Minneapolis, MN) |
| MSFC | Melbourne Science Fiction Club (Melbourne, Australia) |
| MSFC | Malia and Sasha Fan Club (Obama children) |
| MSFC | Million Standard Cubic Feet (gas measurement) |
| MSFC | Microsoft Foundation Classes |
| MSFC | Mobile Strike Force Command (US Army Special Forces) |
| MSFC | Mighty Sad Funpu Chicken (gaming group) |
| MSFC | Marine Sciences and Fisheries Centre (Oman) |