| Acronym | Definition |
|---|
| MSFS | Microsoft Flight Simulator |
| MSFS | Master of Science in Forensic Science (degree) |
| MSFS | Master of Science in Financial Services |
| MSFS | Mail Slot File System |
| MSFS | Microsoft File System |
| MSFS | Missile Security Forces Squadron (USAF) |
| MSFS | Master of Science in Foreign Service |
| MSFS | Missionaries of St. Francis de Sales |
| MSFS | Maximum Safe Free Speed |
| MSFS | Money Source Financial Services (Ann Arbor, MI) |
| MSFS | Manned Space Flight Support |
| MSFS | Mobilités Spatiales Fluidités Sociales |
| MSFS | Message-Passing Stochastic False Sharing |
| MSFS | Moore Stephens Financial Services (UK) |
| MSFS | Moulton School Foot Soldiers (gaming clan) |
| MSFS | Master of Science in Financial Management and Information Systems (graduate degree) |