| Acronym | Definition |
|---|
| NSC | National Security Council |
| NSC | National Safety Council (since 1913) |
| NSC | Norfolk Southern Corporation |
| NSC | National SCRABBLE Championship |
| NSC | National Semiconductor Corporation |
| NSC | National Supplier Clearinghouse |
| NSC | National Sports Commission (Nigeria) |
| NSC | National Skin Centre (Singapore) |
| NSC | Natural Stone Council (various locations) |
| NSC | National Sports Council |
| NSC | Nevada State College (Henderson, NV) |
| NSC | New Shopping Center (Manali Hill, India) |
| NSC | Nippon Steel Corporation |
| NSC | National Steering Committee |
| NSC | Neural Stem Cell |
| NSC | Network Services Company (Schaumburg, IL) |
| NSC | National Sporting Club (UK) |
| NSC | Null Sector |
| NSC | Network Support Center |
| NSC | Network Storage Controller |
| NSC | Net Show Channel |
| NSC | Network Software Center |
| NSC | Natick Soldier Center (US Army) |
| NSC | Nomura Securities Co., Ltd. (Japan) |
| NSC | New Strategic Concept (NATO) |
| NSC | National Security Cutter |
| NSC | NOx Storage Catalyst (chemistry) |
| NSC | National Science Council of Taiwan |
| NSC | Network and Sharing Center (software) |
| NSC | National Sales Company (various locations) |
| NSC | National Service Center |
| NSC | National Science Center |
| NSC | Non-Stick Coating (cookware) |
| NSC | National Security Committee |
| NSC | North Sydney Council (Sydney, Australia) |
| NSC | Network Service Center |
| NSC | Non-Service Connected |
| NSC | National Safety Compliance, Inc. (various locations) |
| NSC | Nuclear Suppliers Group |
| NSC | Nonstructural Carbohydrates |
| NSC | National Software Centre (Ireland) |
| NSC | Northern Short Course (photojournalism) |
| NSC | Northern South Carolina |
| NSC | Nikken Sekkei Civil Engineering Ltd. (est. 2001; Japan) |
| NSC | Naval Supply Center |
| NSC | National Simulation Center |
| NSC | National Securities Commission (Romania) |
| NSC | Neuroscience Center |
| NSC | National Support Center |
| NSC | Network Security Consulting (various locations) |
| NSC | N Scale Collector Society (model railways) |
| NSC | New Secondary Curriculum (UK) |
| NSC | Navy Safety Center (US Navy) |
| NSC | Normal Strength Concrete |
| NSC | Northshore Senior Center (Washington) |
| NSC | Network Systems Corporation |
| NSC | North Shore Cyclists (Massachusetts) |
| NSC | Northern Sun Conference (now Northern Sun Intercollegiate Conference; sports) |
| NSC | National Student Competition |
| NSC | Naval Space Command |
| NSC | Naval Sea Cadet |
| NSC | North Spokane Corridor |
| NSC | North Sioux City (South Dakota) |
| NSC | Neighborhood Shopping Center |
| NSC | Newcastle Science City (UK) |
| NSC | No Significant Clouds (meteorology, aviation) |
| NSC | Network Sharing Camera (Sony) |
| NSC | National Security Center |
| NSC | Network Systems Central (computing: Long Beach, CA) |
| NSC | Nonprofit Service Center (Texas) |
| NSC | National Surgery Centers |
| NSC | Nonprofit Support Center (various locations) |
| NSC | Necessary and Sufficient Condition |
| NSC | National Skin Centre, Singapore |
| NSC | Nonmyelinating Schwann Cell |
| NSC | Number System Character (first digit of UPC) |
| NSC | National Sound Corporation |
| NSC | Northern Studies Centre (various locations) |
| NSC | Network Support Company |
| NSC | National Suppliers Council |
| NSC | Netherlands Society of Cinematographers |
| NSC | No Share Capital (business type, UK) |
| NSC | Neighborhood Services Coordinator |
| NSC | Nominated Sub-Contract |
| NSC | National Seed Corporation (India) |
| NSC | National Starch and Chemical Co |
| NSC | Nippon Scientific Co., Ltd. (est. 1987; Japan) |
| NSC | National Standard of Canada (Standards Council of Canada) |
| NSC | NATO Security Committee |
| NSC | National Software Competition |
| NSC | Nation Song Contest |
| NSC | NATO (North Atlantic Treaty Organization) Shipping Centre (UK) |
| NSC | Non-Standard (Facilities) Command (Itu-T Rec. T.30) |
| NSC | Network Security Controller |
| NSC | Network Security Conference (Las Vegas, NV) |
| NSC | Northern Silviculture Committee |
| NSC | National Storytelling Conference |
| NSC | Noble Society of Celts (est. 1993) |
| NSC | National Staff Coach (soccer) |
| NSC | Non-Standard Facilities Command |
| NSC | Nouvelles Sport Canadien (French: Canadian Sport News) |
| NSC | Network Service Controller |
| NSC | Nursing Student Council (various universities) |
| NSC | Nomenclature Standards Committee (FDA) |
| NSC | NATO Supply Center (NAMSA) |
| NSC | Node Site Coordinator |
| NSC | Nuclear Sciences Center |
| NSC | Noise Suppression Circuit |
| NSC | North Star Camp (Tucson, Arizona) |
| NSC | Network Surveillance Center |
| NSC | National Seismic Conference |
| NSC | National Science Collections (Alliance) |
| NSC | Non-Submarine Contact |
| NSC | Naval Support Center |
| NSC | Newmarket Stage Company |
| NSC | Nuclear Services Corporation |
| NSC | New System Concept |
| NSC | NATO Steering Committee |
| NSC | Nursing Station Clerk |
| NSC | non-sinusoidal carrier |
| NSC | NATO Standardization Committee |
| NSC | Northeastern School of Commerce (Bay City, Michigan) |
| NSC | NATO Surveillance Coordination Center |
| NSC | Non-Linear Stabilizing Control (control system type) |
| NSC | Non Specification Contaminants |
| NSC | Nihon Suido Consultants, Ltd (Japan) |
| NSC | Navigation Set Computer (LANTIRN) |
| NSC | Noiseless Source Coding |
| NSC | Non Segmented Client |
| NSC | Nuclear Sclerosis Cataract |
| NSC | Noisy Subband Component |