| Acronym | Definition |
|---|
| NFL | National Football League |
| NFL | Newfoundland (Canada) |
| NFL | No Fun League |
| NFL | Not For Long |
| NFL | National Forensic League |
| NFL | Niagra Falls (Amtrak station code; Niagra Falls, NY) |
| NFL | Nachrichten für Luftfahrer (German: Notices to Airmen; German Air Traffic Control) |
| NFL | Negative Feedback Loop |
| NFL | Narrow Flood Light (lightbulb) |
| NFL | Never Forget Loyalty |
| NFL | No Free Lunch |
| NFL | National Fertilizer Limited (est. 1974; India) |
| NFL | New Found Love |
| NFL | No Friends Left |
| NFL | Nerve Fiber Layer |
| NFL | Npower Football League (UK) |
| NFL | NAS Fallon (Naval Air Station; Nevada) |
| NFL | National Foods Limited (various locations) |
| NFL | Northumberland Ferries Limited (Canada) |
| NFL | Non-Fermi Liquid |
| NFL | National Food Laboratory (California) |
| NFL | National Federation of Labor |
| NFL | Non-Federal Levee (US Army) |
| NFL | National Forensic Laboratory |
| NFL | Nyungwe Forest Lodge (Rwanda) |
| NFL | No-Fire Line |
| NFL | No Freakin' Lime |
| NFL | Not Freakin' Likely |
| NFL | New Foreign Launch (military launch detection) |
| NFL | Norwegian Defence Industry Group |
| NFL | Nerd for Life |
| NFL | Noise Floor Level |
| NFL | Navigation Feature Layer |
| NFL | Neue Fünf Länder (the states of former East Germany) |
| NFL | Near, Far Line (marine engineering; US DoD) |