| Acronym | Definition |
|---|
| MUSE | Musicians United for Safe Energy (est. 1979) |
| MUSE | Multi User Simulation Environment |
| MUSE | Multi-User Simulation Environment |
| MUSE | Multiple Sub-Nyquist Sampling Encoding |
| MUSE | Medicated Urethral System for Erections |
| MUSE | Multiple Unified Simulation Environment |
| MUSE | Mobile Utilities Support Equipment |
| MUSE | Multi-University Systems Education (various schools) |
| MUSE | Multiple UAV Simulation Environment |
| MUSE | Multi User System Environment (ARINC) |
| MUSE | Multi User Shared Experience |
| MUSE | Method for User Interface Engineering (University of Oldenburg, Germany) |
| MUSE | Mapping, Charting, and Geodesy Utility Software Environment |
| MUSE | MC&G Utility Software Environment |
| MUSE | Mainstream US English (linguistics) |
| MUSE | Marquette Universal System for Electrocardiography |
| MUSE | Mobile Ultrasonic Equipment |
| MUSE | Monitor Ultraviolet Solar Energy |
| MUSE | Multiple Unmanned Aerial Vehicle Simulation Environment |
| MUSE | McGill University Online Library Catalogue |
| MUSE | Miami University Simulation Environment |