| Acronym | Definition |
|---|
| OPEN | Object-Oriented Process, Environment, and Notation (OPEN Consortium) |
| OPEN | Online Protection and Enforcement of Digital Trade Act |
| OPEN | Open Protocol Enhanced Network |
| OPEN | Object Oriented Process Environment and Notation |
| OPEN | Oregon Public Education Network |
| OPEN | Open Platform for Emergency Networks |
| OPEN | Online Public Education Network |
| OPEN | One Planet Education Network |
| OPEN | Open Protocol Enhanced Networks |
| OPEN | Optical Pan-European Network |
| OPEN | Ontario Provincial Education Network (Ontario, Canada) |
| OPEN | Olympic and Paralympic Employment Network (UK) |
| OPEN | Oncovin, Prednisone, Etoposide, Novantrone |
| OPEN | Origins of Plasma in the Earth's Neighborhood |