| Acronym | Definition |
|---|
| PROBE | Proxy Based Estimating (software development) |
| PROBE | Public Report on Basic Education in India (1999) |
| PROBE | Provincial Broadband Extension (New Zealand) |
| PROBE | Program Optimization & Budget Evaluation |
| PROBE | Pilot Radiation Observation Experiment (Atmospheric Radiation Measurement Climate Research Facility; US Department of Energy) |
| PROBE | Prospective, Randomized, Open, Blinded End-Point (clinical trial design) |
| PROBE | Personal Research on Basically Everything (education) |
| PROBE | Preternatural Research Bureau (Doctor Who spinoff series) |
| PROBE | Project Review and Objective Evaluation (health records; UK) |
| PROBE | Prose Reading Observation Evaluation (New Zealand) |