OSRS
| Acronym | Definition |
|---|---|
| OSRS | Old School RuneScape (gaming) |
| OSRS | Ohio State Radiological Society (est. 1940) |
| OSRS | Ocean Sciences Research Section (US NSF) |
| OSRS | Operation Safety Requirements Specification |
| OSRS | Oil Spill Response Systems |
| OSRS | Orbital Structural Reference System |
| OSRS | Old Scratch Revival Singers (band) |