| Acronym | Definition |
|---|
| ORF | Open Reading Frame (genetics) |
| ORF | Open Reading Frame (genome) |
| ORF | Observer Research Foundation (India) |
| ORF | Organic Rye Flour |
| ORF | Oral Reading Fluency |
| ORF | Oesterreichischer Rundfunk (Austrian Broadcasting Corporation) |
| ORF | Oesterreichischer Rundfunk (Austrian radio and television company) |
| ORF | Open Reading Frame |
| ORF | Olympus Raw File |
| ORF | Open Research Forum (various locations) |
| ORF | Onshore Receiving Facilities |
| ORF | Outbound Route Filter (Cisco) |
| ORF | Olympus Raw Format (file extension) |
| ORF | Operational Readiness Float |
| ORF | Oceanic Resource Foundation |
| ORF | Order Request Form (various organizations) |
| ORF | Operations Research and Facilities |
| ORF | Official Representation Funds |
| ORF | Norfolk, VA, USA - Norfolk International Airport (Airport Code) |
| ORF | Ontario Research Foundation (now ORTECH International) |
| ORF | Ohio Renaissance Festival (Wilmington, Ohio) |
| ORF | Ontario Renaissance Festival (Milton, Ontario) |
| ORF | Old Retired Fart |
| ORF | Organisation Rotaract de la Francophonie (French Rotary club) |
| ORF | Orbital Reference Frame |
| ORF | Outside Right Forward (soccer) |
| ORF | Our Retired Friends |