| Acronym | Definition |
|---|
| ONE | Operation Noble Eagle |
| ONE | Orchestra New England (New Haven, CT) |
| ONE | Office of Nuclear Energy |
| ONE | Overclocking Navigator Engine |
| ONE | Open Network Environment |
| ONE | Open Network Exchange |
| ONE | Omnifunctional Network Environment |
| ONE | Optical Network Element |
| ONE | Office de la Naissance et de l'Enfance (Belgium: Birth and Child Office) |
| ONE | Open Network Environment (Netscape) |
| ONE | Open Net Environment (Sun) |
| ONE | Organization of the NorthEast (Chicago, Illinois) |
| ONE | Operation Nest Egg |
| ONE | Online Networking for the Environment |
| ONE | Office of National Estimates (National Intelligence Council) |
| ONE | Office National d'Electricite |
| ONE | Other Network Entities |
| ONE | Organic & Natural Enterprise Group (Australia) |
| ONE | Odaiko New England (Arlington, MA) |
| ONE | One pulmonary Artery (or hypoplasia), Neoplasm, Embolism |
| ONE | One Nation Earth |
| ONE | One Network for Everyone |
| ONE | Optical Network Element (NEC) |
| ONE | Ozarks New Energy (Springfield, MO) |
| ONE | Oceanic Navigational Error |
| ONE | Open Network Expansion |
| ONE | Office Network Exchange (Honeywell) |
| ONE | Optimized Network Evolution (Siemans/Stromberg-Carlson) |
| ONE | Office National de l'Énergy (National Energy Board - Canada) |
| ONE | Ossific Nucleus Eccentricity |
| ONE | Out-of-Nest Episodes (psychology) |