| Acronym | Definition |
|---|
| OSU | Ohio State University (The) |
| OSU | Oklahoma State University |
| OSU | Oregon State University |
| OSU | Optical Switching Unit |
| OSU | Oracle Software Upgrade |
| OSU | Open System Utilities |
| OSU | Optical Service Unit |
| OSU | Optical Subscriber Unit |
| OSU | Oswego State University (fka SUNY Oswego) |
| OSU | The Ursulines (religious order) |
| OSU | Shore Units Division (US Navy) |
| OSU | Officially Sanctioned User |
| OSU | Onomastic Studies Unit (South Africa) |
| OSU | Optical Scan Unit |
| OSU | Optical Scanning Unit |
| OSU | On-orbit Serviceable Unit |
| OSU | Optical Stimulation Unit |
| OSU | Oceanographic Support Unit |
| OSU | Operators Support Unit |