| Acronym | Definition |
|---|
| OTE | On the Edge |
| OTE | Off Topic Experiment |
| OTE | Operating to Endanger (motor vehicle law; Massachusetts) |
| OTE | Over the Edge (game/movie) |
| OTE | Opportunity to Earn |
| OTE | On-Target Earnings |
| OTE | Off Tackle Empire (football blog) |
| OTE | Ordinary Time Earnings |
| OTE | Open Transaction Environment (IBM mainframes CICS) |
| OTE | Hellenic Telecommunications Organisation (Greece) |
| OTE | Oxygen Transfer Efficiency (water and wastewater treatment) |
| OTE | Optical Telescope Element |
| OTE | Optical Terminal Enclosure (various companies) |
| OTE | Oberon Theatre Ensemble (New York) |
| OTE | Open Translation Engine |
| OTE | Office of Training and Education |
| OTE | One Time Exception |
| OTE | Organization for Timeshare in Europe |
| OTE | Office of Technology Evaluation |
| OTE | Over Track Exhaust (transportation ventilation system) |
| OTE | Overtaken by Events |
| OTE | Operational Test & Evaluation |
| OTE | Onward to Excellence (school improvement process/program) |
| OTE | Omron Taiwan Electronics, Inc. |
| OTE | Open Trade Equity |
| OTE | Orbital Tissue Expander (ophthalmology) |
| OTE | Optically Transparent Electrode |
| OTE | OceanTech Expo |
| OTE | Options Through Education (Boston College) |
| OTE | Office of Transportation Economics (California) |
| OTE | Operational Test Environment |
| OTE | Off Track Excursion (auto racing) |
| OTE | Observing Time Estimator |
| OTE | Operator Training Equipment |
| OTE | Overtime Equalization |
| OTE | Oman Trading Establishment LLC |
| OTE | Organismos Tilepikinonion Ellados AE (Greek: Hellenic Telecommunications Organization) |
| OTE | Operator Training and Evaluation |
| OTE | Office des Tunisiens al'Etranger |
| OTE | Onset of Thermal Excursion |
| OTE | Ottoman-Turk Empire |
| OTE | Own-Ship Trajectory Estimator |
| OTE | One Task Extension |
| OTE | Owner's Trust Equity (financial modelling) |
| OTE | Output Energized (PLC programming) |
| OTE | Overall Total Earnings |