| Acronym | Definition |
|---|
| SISC | Standard Instruction Set Computing/Computing |
| SISC | Security Income Status Code |
| SISC | Single Instruction Set Computer |
| SISC | Simple Instruction Set Computer |
| SISC | Sony India Software Centre (India) |
| SISC | Società Italiana per lo studio delle cefalee (Italian) |
| SISC | Self-Insured Schools of California |
| SISC | Second Interpreter of Scheme Code |
| SISC | Semiconductor Interface Specialists Conference |
| SISC | Southville International School and Colleges (Philippines) |
| SISC | Society for International Space Cooperation |
| SISC | Système d'Information de l'Association des Scouts du Canada (French: Information System of the Scout Association of Canada) |
| SISC | Science and Infrastucture Steering Committee (various organizations) |
| SISC | Simulation Interoperability Standards Committee (standards committee for the IEEE Computer Society) |
| SISC | Standard Information Systems Center |
| SISC | Side-Information Source Code |
| SISC | Simple Instruction Set Chip |
| SISC | SMils International Summer Camps |
| SISC | SSI Status Code |
| SISC | Senate Internal Security Subcommittee |