PYSC
| Acronym | Definition |
|---|---|
| PYSC | Peninsula Youth Soccer Club (Foster City, CA) |
| PYSC | Portishead Yacht and Sailing Club (North Somerset, UK) |
| PYSC | Peterborough Youth Soccer Club (Ontario, Canada) |
| PYSC | Plymouth Youth Sailing Club (UK) |
| PYSC | Pearland Youth Soccer Club (Pearland, TX) |
| PYSC | Pittsburgh Youth Soccer Club (now Kingston United Soccer Club; Kingston, Ontario, Canada) |
| PYSC | Parietal Yolk Sac Carcinoma (cancer) |