| Acronym | Definition |
|---|
| OTK | Over The Knee |
| OTK | Oikeustieteen Kandidaatti (Finnish: Master of Law) |
| OTK | One Turn Kill (card gaming) |
| OTK | On That Kush (band) |
| OTK | Open Tool Kit (graphical user interface programming library) |
| OTK | One Time Key |
| OTK | On The Kop (Liverpool FC website) |
| OTK | Out To Kill (gaming) |
| OTK | One-Tailed Kyuubi |
| OTK | Off the Keyboard |
| OTK | Operate to Know (US Office of Naval Research) |
| OTK | Osaka Toshi Kaihatsu (Japanese: Osaka Prefectural Urban Development) |
| OTK | Original Tony Kart |
| OTK | Office Tool Kit |
| OTK | Overtake the King (band) |
| OTK | Owner of the Katana (Halo Seventh Column group) |