| Acronym | Definition |
|---|
| OTR | Over The Road (truckers) |
| OTR | On the Real |
| OTR | Other |
| OTR | Office of Tax and Revenue |
| OTR | Old Time Radio |
| OTR | On the Record |
| OTR | Over the River |
| OTR | Office of Trade Relations (US Customs and Border Protection) |
| OTR | Over-The-Rhine (Cincinnati, Ohio neighborhood) |
| OTR | Original Theatrical Release (movies) |
| OTR | On The Road |
| OTR | Off the Record |
| OTR | Outer |
| OTR | Off-The-Road (vehicles/tires) |
| OTR | On the Run |
| OTR | Optical Transponder (Nortel Networks Corporation) |
| OTR | Online TV Recorder (software) |
| OTR | Over The Rainbow |
| OTR | Occupational Therapist, Registered |
| OTR | On the Rocks |
| OTR | Output Routine |
| OTR | Optical Transceiver |
| OTR | One Touch Recording |
| OTR | Operational Test Requirement |
| OTR | Operational Trouble Report |
| OTR | Ozone Transport Region (EPA) |
| OTR | Oxygen Transmission Rate |
| OTR | Optical Transition Radiation |
| OTR | One Touch Recording (VCRs) |
| OTR | Oxytocin Receptor |
| OTR | Olympic Torch Relay |
| OTR | Over-The-Range (microwave oven) |
| OTR | Off the Rack |
| OTR | Operating Temperature Range |
| OTR | Order-To-Remittance |
| OTR | On The Rag |
| OTR | Old Timers Reunion |
| OTR | Official Transcript of Records |
| OTR | Oakland Terminal Railway |
| OTR | Obecná Teorie Relativity (Czech: general theory of relativity) |
| OTR | Overhead Transfer Rate |
| OTR | Optical Tracking |
| OTR | Oceanic Transition Route |
| OTR | Off-The-Rail |
| OTR | Other Than Rock |
| OTR | Operational Turn Round |
| OTR | Order to Receipt |
| OTR | Originale Trasmissione del Ritmo (band) |
| OTR | Opportunity To Recall |
| OTR | Operational Test Readiness |
| OTR | Operability Test Report |
| OTR | Outyear Threat Report |
| OTR | Out-Of-Tolerance Report |
| OTR | Officer Technical Refresh |
| OTR | Coto 47 Airstrip, Costa Rica (Airport code) |
| OTR | Overall Tuning Range |
| OTR | One Time Requisition |
| OTR | Organization of the Top Rappers |
| OTR | Order to Requisition |