| Acronym | Definition |
|---|
| OPU | Okayama Prefectural University (Okayama, Japan) |
| OPU | Optical Pickup Unit |
| OPU | Older Persons Unit (UK) |
| OPU | Ovum Pick-Up |
| OPU | Overcloud Processing Unit (computing) |
| OPU | Office des Publications Universitaires |
| OPU | Order Prohibiting Use (US OSHA; California) |
| OPU | Optical Pickup Head (DVD drives) |
| OPU | Optical Channel Payload Unit |
| OPU | OnPlayerUpdate (computing) |
| OPU | Offshore Production Unit (various locations) |
| OPU | Oil Pick Up (spinning) |
| OPU | Outstation Processing Unit |
| OPU | Overseas Plexiglass Unit (US Navy) |
| OPU | Organisations Psykologisk Uddannelse (Danish) |
| OPU | Ottawa Panhandlers' Union (Canada) |
| OPU | Operational Performance Unit |
| OPU | Operating Partnership Unit (investing) |