| Acronym | Definition |
|---|
| OTSS | Open System Transport and Session Support |
| OTSS | Ontario Trust for Student Support (Ontario, Canada) |
| OTSS | Ottawa Technical Secondary School (Ottawa, Canada) |
| OTSS | Only the Strong Survive (movie) |
| OTSS | Online Tutor Sign-Up System (University of California, Santa Cruz) |
| OTSS | Operations Technology and Shared Services |
| OTSS | On The Safe Side (London, UK) |
| OTSS | Operational Telecommunications Switching System |
| OTSS | Office of Technical Support Services |
| OTSS | Operations Traffic Switching System |
| OTSS | Oita TS (Toshiba/Sony) Semiconductor (Japan) |