| Acronym | Definition |
|---|
| OWLS | Outagamie Waupaca Library System (Wisconsin) |
| OWLS | Oregon Weight Loss Surgery (Portland, OR) |
| OWLS | Organized Workers for Labor Solidarity (Seattle, WA) |
| OWLS | Outdoor Wildlife Learning Site |
| OWLS | Older Wiser Laughing Souls |
| OWLS | Outdoor Wilderness Leadership School (est. 1996; Montana and Virginia) |
| OWLS | Oxford Word and Language Service |
| OWLS | Optical Waveguide Light Mode Spectroscopy (biology) |
| OWLS | Outdoor Wisconsin Leadership Synergies (George Williams College of Aurora University) |
| OWLS | One-Way Light Speed Experiment (physics) |
| OWLS | Ocala Wild Life Sanctuary (Florida, USA) |