SISD
| Acronym | Definition |
|---|---|
| SISD | Single Instruction Single Data |
| SISD | Socorro Independent School District (El Paso, TX) |
| SISD | Southeast Island School District (Alaska) |
| SISD | Southwest Independent School District (Texas) |
| SISD | Stocks and Internal Shipping Department |
| SISD | Software and Information Systems Division (NASA) |