| Acronym | Definition |
|---|
| OFS | Out for Season (various sports) |
| OFS | Offset |
| OFS | Office Fédéral de la Statistique (French: Federal Office of Statistics; Switzerland) |
| OFS | Original File System |
| OFS | Orden Franciscana Seglar (Spanish: Secular Franciscan Order) |
| OFS | One Finger Salute (band) |
| OFS | Oil Field Service |
| OFS | Offer for Sale |
| OFS | Operation Freedom’s Sentinel |
| OFS | Operation Food Search (St. Louis, MO) |
| OFS | Offshore (oil and gas industry) |
| OFS | Output Field Separator |
| OFS | Office of Frontier Security (Honor Harrington science fiction novels) |
| OFS | Optical Fiber System |
| OFS | Optical Fiber Solutions |
| OFS | Open File System |
| OFS | Object File Store |
| OFS | Open File Server |
| OFS | Optical File System |
| OFS | Open Framework System |
| OFS | Oracle Fail Safe |
| OFS | Open File Support |
| OFS | Operational Fixed Service |
| OFS | Open from Start |
| OFS | Open Financial Solutions |
| OFS | Object File System |
| OFS | Ordo Franciscanus Saecularis (Latin: Secular Franciscan Order) |
| OFS | Overseas Family School (Singapore) |
| OFS | Orange Free State |
| OFS | Oklahoma Flute Society |
| OFS | Office of Family Services (various organizations) |
| OFS | Oklahoma Forestry Services (Oklahoma) |
| OFS | Optical Frequency Standards |
| OFS | Office of Field Service (US Navy) |
| OFS | Online Financial Services (Wells Fargo) |
| OFS | Optical Fiber Sensor |
| OFS | Oh, for Sure! |
| OFS | Oxford Fieldpaths Society (UK) |
| OFS | Oberlin Film Series (Oberlin College; Ohio) |
| OFS | Order Fulfillment System |
| OFS | Occupational Field Sponsors (US Marine Corps) |
| OFS | Oil Fired Station |
| OFS | Office of Field Specialists (IRS) |
| OFS | Ontario Federation of Students |
| OFS | Oakland Family Services |
| OFS | Operational Fixed Service (FCC) |
| OFS | Operational Flight Simulator |
| OFS | Out-of-Frame Second (SONET) |
| OFS | Optics Free Spectrometer |
| OFS | Order of Free State |
| OFS | Orbital Flight System |
| OFS | Ottawa Fire Service |
| OFS | Officer Foundation System |
| OFS | Ongoing Feedback System |
| OFS | Obligation Forecasting System |
| OFS | Out for Signature (leases) |