| Acronym | Definition |
|---|
| POTW | Player of the Week |
| POTW | Publicly Owned Treatment Works |
| POTW | Picture of the Week |
| POTW | Pick of the Week |
| POTW | President of the World |
| POTW | Project of the Week |
| POTW | Post of the Week |
| POTW | Poem of the Week (website) |
| POTW | Problem of the Week (education) |
| POTW | Pokemon of the Week (video gaming) |
| POTW | Patient of the Week (House, TV show) |
| POTW | Paragraph of the Week (education) |
| POTW | Patents on the Web |
| POTW | Pizza of the Week |
| POTW | Parting of the Ways (Doctor Who) |
| POTW | Pipers of the World |
| POTW | Peek of the Week |
| POTW | Princess of the World (Barbie dolls) |
| POTW | Point Out the Women (Dota clan) |
| POTW | Punisher of the Weak (gaming website) |
| POTW | Publicly Operated Treatment Work |