| Acronym | Definition |
|---|
| OSB | Oriented Strand Board |
| OSB | Oracle Service Bus |
| OSB | Oregon State Bar (Lake Oswego, Oregon) |
| OSB | Office of State Budget (various locations) |
| OSB | Old Saybrook (Amtrak station code; Old Saybrook, CT) |
| OSB | Olayan School of Business (American University; Lebanon) |
| OSB | Order of Saint Benedict |
| OSB | Open Source Blog |
| OSB | Open Speech Browser |
| OSB | Operations Software Branch |
| OSB | Oracle Secure Backup |
| OSB | Off Site Branch |
| OSB | Oem for System Builder |
| OSB | Office of the Superintendent of Bankruptcy (Canada) |
| OSB | Osama Bin Laden |
| OSB | Otentikk Street Brothers (musicians) |
| OSB | One Step Beyond |
| OSB | Ordinis Sancti Benedicti (of the order of St Benedict) |
| OSB | Orquestra Sinfônica Brasileira (Portugese) |
| OSB | Overbrook School for the Blind (Philadelphia, PA) |
| OSB | Orthodox Study Bible |
| OSB | Online Services Business (Microsoft business segment) |
| OSB | Office Shortcut Bar (Microsoft Office) |
| OSB | Office of Surveillance and Biometrics (Center for Devices and Radiological Health; US FDA) |
| OSB | Offset Spoke Bed (bicycle wheels) |
| OSB | Operations Support Building |
| OSB | Optimization and Systems Biology (Symposium) |
| OSB | Officer Selection Battery |
| OSB | Oregon Symphonic Band (Portland, OR) |
| OSB | Operations Support Branch |
| OSB | Optimal Spectrum Balancing |
| OSB | Output Signal Balance |
| OSB | One Shot Battery |
| OSB | Other Sports Beckon |
| OSB | OpenSG Binary (a 3D file format/extension) |
| OSB | Overseas Service Bar |
| OSB | Operational Stations Book |
| OSB | Officer Selection Brief |
| OSB | Old School Books |
| OSB | Originally Signed By |
| OSB | Operation Shoe Box |
| OSB | Oberes Seitenband (German: upper sideband) |
| OSB | Option Select Button |
| OSB | Operation Stations Book |
| OSB | Oriental Satellite Broadcasting |
| OSB | Operational Service Bulletin |
| OSB | Openshop Business |
| OSB | Order of Shepherds of Bethlehem |
| OSB | Official Sealed Bid (Wisconsin state procurement) |
| OSB | Over-Determined Sub-Band |
| OSB | Ortssippenbuch, Familienbuch or Ortsfamilienbuch (German) |