| Acronym | Definition |
|---|
| PRL | Perl Programming Language (filename extension) |
| PRL | Polo Ralph Lauren |
| PRL | Physical Review Letters |
| PRL | Pattern Recognition Letters |
| PRL | Prolactin (medical) |
| PRL | Prevención de Riesgos Laborales |
| PRL | Preferred Roaming List (cellular phones) |
| PRL | Plan Rozwoju Lokalnego (Polish: Local Development Plan) |
| PRL | Preferred Retinal Locus (vision) |
| PRL | Physical Research Laboratory (India) |
| PRL | Packet Reverb Lockout |
| PRL | Preferred Roaming List |
| PRL | Pittsburgh Research Laboratory |
| PRL | Parti Réformateur Libéral (Belgium Liberal Reformation Party) |
| PRL | Polska Rzeczpospolita Ludowa (Poland) |
| PRL | Plant Research Laboratory (Michigan State University) |
| PRL | Probabilistic Record Linkage (healthcare) |
| PRL | Philips Research Laboratories (IRedhill, England) |
| PRL | Plasma Research Laboratory |
| PRL | Parcs Résidentiels de Loisirs (French: Residential Leisure Parks) |
| PRL | Photo Red Light (various locations) |
| PRL | Population Research Laboratory (University of Alberta) |
| PRL | Prioritized Requirements List |
| PRL | Plagas Removal Laser (Resident Evil 4 game) |
| PRL | Pakistan Refinery Ltd |
| PRL | Phosphate Resources Limited (Christmas Island) |
| PRL | Photonics Research Laboratory (University of Melbourne, Australia) |
| PRL | Process Readiness Level |
| PRL | Production Rule Language |
| PRL | Program Related Logistics |
| PRL | Plaga Removal Laser |
| PRL | Primate Research Laboratory (part of the NIH animal research program) |
| PRL | Post Rate Limit |
| PRL | Port Rail Line (Hong Kong) |
| PRL | Personnel Research Lab |
| PRL | Program Requirements List |
| PRL | Professional Renewal Leave (LANL) |
| PRL | Pulse Rebalance Loop |
| PRL | Program Requirements Logic |
| PRL | Program Review Memorandum |
| PRL | Publications Requirements List |
| PRL | Programmatic Readiness Level |