| Acronym | Definition |
|---|
| OMB | Office of Management & Budget (US government; also seen as USOMB) |
| OMB | Ontario Municipal Board (Government of Ontario) |
| OMB | Oregon Medical Board (Portland, OR) |
| OMB | Oracle Meta Base |
| OMB | Original Muscle Beach (Santa Monica, CA) |
| OMB | One Man Band |
| OMB | Only Make Believe (theater group; New York) |
| OMB | Oh My Bad (fault slang) |
| OMB | Oh My Bieber |
| OMB | Optical Media Board (Philippines) |
| OMB | Owner Managed Business (various companies) |
| OMB | Official Match Ball (Adidas) |
| OMB | Open Media Boston (Media Working Group; Boston, MA) |
| OMB | Operational Management Board (infrastructure; EU) |
| OMB | Online Marketing Blog |
| OMB | Osteopathic Medical Board (California) |
| OMB | Open Manufacturing Backbone (software; UGS) |
| OMB | Oregon Marching Band (University of Oregon) |
| OMB | Official Message Board |
| OMB | Oh My Buddha |
| OMB | Obtuse Marginal Branch |
| OMB | Oh My Bob |
| OMB | Operations Manual Bulletin |
| OMB | Outer Marker Beacon (aviation) |
| OMB | Originating Message Buffers |
| OMB | Optical Mounting Board |
| OMB | Order of Mapungubwe: Bronze (South Africa) |
| OMB | Organizational Mailbox (US Air Force) |