OPFC
| Acronym | Definition |
|---|---|
| OPFC | Orlando Pirates Football Club (South Africa) |
| OPFC | Old Pauline Football Club (UK) |
| OPFC | Orbital Prefrontal Cortex (neurobiology) |
| OPFC | One Piece Fan Club (Japanese comic fan group) |
| OPFC | Ohio Public Facilities Commission |
| OPFC | Old Parmiterians Football Club (UK) |