| Acronym | Definition |
|---|
| OPL | Ottawa Public Library (Ottawa, Ontario, Canada) |
| OPL | Open Programming Language |
| OPL | Operator Plmn List |
| OPL | Open Content License |
| OPL | outer plexiform layer |
| OPL | Open Publication License |
| OPL | On-Premise Laundry |
| OPL | Odisha Premier League (Indian cricket league) |
| OPL | Opinion Leader |
| OPL | Optical Path Length |
| OPL | One Planet Living (global initiative) |
| OPL | Open Publishing Lab |
| OPL | Off Port Limit (shipping industry) |
| OPL | Oceanside Public Library (various locations) |
| OPL | Office of Public Liaison |
| OPL | Organiser Programming Language (PSION) |
| OPL | Overhead Power Line (electric power transmission) |
| OPL | Outpost Line (US Navy) |
| OPL | Open Public License |
| OPL | Other Party Liability (insurance) |
| OPL | Output Protection Limiting (audio equipment) |
| OPL | Optics and Photonics Letters (journal) |
| OPL | One Point Lesson |
| OPL | Operations Log (oil exploration) |
| OPL | OpenContent Licence |
| OPL | One Person Librarian |
| OPL | FM Operator Type-L (audio synthesiser chip) |
| OPL | Over Prescribed Limit (drunk driving) |
| OPL | Office of Public Leadership (University of Illinois) |
| OPL | Oil Prospecting Lease |
| OPL | Order of Preachers Layperson (Roman Catholicism; Dominican) |
| OPL | Outer Port Limit (shipping) |
| OPL | Olympus Product Line (Sun) |
| OPL | Operating Parameter Limit |
| OPL | Office of Policy and Legislation (US) |
| OPL | Operator Performance Lab (University of Iowa Engineering Research Laboratory) |
| OPL | Optical Power Limiter (Delaire) |
| OPL | Oxford Property Lettings (Dublin, Ireland) |
| OPL | Òganizasyon Pèp K ap Lite (Bangla: Struggling People's Organization, Haiti) |
| OPL | One Percent Living |
| OPL | Outside Plant Loss (Lucent) |
| OPL | Oil Publications Limited |
| OPL | Ohio Pink Ladies (Toledo, OH) |
| OPL | optional port of loading |
| OPL | Officer Processing Lead (US DoD) |
| OPL | Organic Pure Life (New York, NY) |
| OPL | Outer Physical Layer |